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DNA Helix

Cofund on Biotechnologies

Innovation for Europe – life science meets market application


Bioprocesses for the optimized, integrated production of butyl esters from sustainable resources

Logo Bester

Coordinator: Dr. Alexander Wentzel, SINTEF Materials and Chemistry, Biotechnology and Nanomedicine, REC, Norway

Ulm University (UULM) Institute of Microbiology and Biotechnology, HES, Germany
Green Biologics Ltd. (GBL), LE, United Kingdom
University of Rostock (UROS), Dept of Systems Biology & Bioinformatics, HES, Germany
Imperial College London (ICL), Centre for Environmental Policy, HES, United Kingdom

Group photo Bester

Source: Dr. Alexander Wentzel / SINTEF Materials and Chemistry


Project Abstract

The BESTER project establishes clostridial bioprocesses for an optimized integrated production of a range of different butyl esters for the commodity chemicals market. Efficient organic acid production using lignocellulosic sugars as a sustainable feedstock are being developed, linkable to ABE fermentation processes on similar feedstock as a source of n-butanol (BuOH). BESTER thereby addresses in a coordinated way the two key handles for efficient production of three different acids, i.e. a) Systems biology driven strain engineering using Synthetic biology principles to establish new acid production in suitable clostridial chassis strains and mitigate key metabolic bottlenecks hampering high productivity, and b) smart process design and integration to prevent inhibitory effects of the acids produced and the BuOH added in efficient bioprocesses with continuous enzymatic ester product formation and recovery.

BESTER is funded by the ERA CoBioTech  partners:  ANR, BMBF, RCN, UKRI-InnovateUK, UKRI-BBSRC and co-funded by the European Union.

Project Start: April 2018  Duration: 36 months  
Project Budget:  Total Cost: 2.842.000 Euro, Funding: 2.119.000 Euro
Project Website:


Project presentation from ACHEMA kick-off meeting

Project presentation status seminar 2021

Project brochure

HES – higher education sector – university
LE – large enterprise
SME – small and medium-sized enterprise