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DNA Helix

Cofund on Biotechnologies

Innovation for Europe – life science meets market application


Thermophilic bacterial and archaeal chassis for extremolyte production.

Logo HotSolute

Coordinator: Prof. Dr. Bettina Siebers, University of Duisburg-Essen, HES, Germany

University of Exeter, HES, United Kingdom
Consiglio Nazionale delle Ricerche, REC, Italy
Evonik Industries AG, LE, Germany
Federal Research Center of Biotechnology, Russian Academy of Sciences, REC, Russia
Stellenbosch University, HES, South Africa

Project Abstract

The HotSolute project aims to provide small molecular compounds so called “extremolytes”, which stabilize cells and their cellular structures under extreme conditions, for biotechnological applications. Extremolytes cannot be produced in the available mesophilic production hosts and therefore two thermophilic hosts, Thermus thermophilus and Sulfolobus acidocaldarius of bacterial and archaeal origin, respectively, will be established as novel platform organisms. Extremolytes possess great potential for application in the cosmetic and health care market.

Group photo HotSolute

Source: Dr. Benjamin Meyer / University of Duisburg-Essen


HotSolute is funded by the ERA CoBioTech partners: BMBF, MIUR, UKRI-BBSRC and co-funded by the European Union.


Project Start: April 2018  Duration: 36 months    

Project Budget: Total Cost: 1.670.000 Euro, Funding: 1.347.000 Euro

Project Website:



Project presentation from ACHEMA kick-off meeting

Project presentation status seminar 2021

Project brochure

HES – higher education sector – university
REC – research organisation
LE – large enterprise