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DNA Helix

Cofund on Biotechnologies

Innovation for Europe – life science meets market application


Engineering microbial communities for the conversion of lignocellulose into medium-chain carboxylates

Logo SynBioMet

Coordinator: Prof. dr. Thomas Walther, Technische Universität Dresden, HES, Germany

REC, France
ESPCI, REC, France
Adisseo, SME, France


Project Abstract

SYNBIOMET project aims at developing a microbial fermentation process to produce 2,4-dihydroxybutyric acid (DHB), which is a precursor of the methionine analogon 2-hydroxy-4-(methylthio)butyrate (HMTB). Since DHB is not a natural metabolite in life cells, we will implement a synthetic metabolic pathway by combining modern enzyme engineering concepts and strain engineering. Research project's approach will enable a more sustainable, sugar-based production of HMTB which, at present, is exclusively produced from fossil resources.

SYNBIOMET is funded by the ERA CoBioTech partners: SMWK and ANR.

Project Start: June 2021   Duration: 36 months  
Project Budget:  Total Cost: 1.522.000 Euro, Funding: 1.029.000 Euro

Project presentation status seminar 2021

Project brochure


HES – higher education sector – university
REC – research organisation
SME – small and medium-sized enterprise