Continuous bioprocessing of microbial co-cultures: directing population by nutrient pulsing based on single cell data
Coordinator: Prof. dr. Frank Delvigne, University of Liège Gembloux, HES, Belgium
Helmholtz-Centre for Environmental Research – UFZ Leipzig, REC, Germany
Puratos NV, SME, Belgium
The ContiBio project aims to control synthetic co-cultures in bioreactors by assembling a modular computational framework to address phenotypic and genetic instabilities arising at a single-cell level. The project will build a cell-machine interface based on our research efforts on microbial population interactions and dynamic single-cell data to transition from batch bioprocesses to continuous ones. This project will provide new technologies enabling the control and stability of continuous cultivation devices by addressing the phenotypic and genetic diversification found for industrial bioprocesses.
ContiBio is funded by the ERA CoBioTech partners: SPW-DGO6, and SMWK.
Project Start: May 2021 Duration: 36 months
Project Budget: Total Cost: 856.000 Euro, Funding: 798.000 Euro
Project Website: https://contibio-cobiotech.com/
HES – higher education sector – university
REC – research organisation
SME – small and medium-sized enterprise