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DNA Helix

Cofund on Biotechnologies

Innovation for Europe – life science meets market application


Continuous bioprocessing of microbial co-cultures: directing population by nutrient pulsing based on single cell data

Logo ContiBio

Coordinator: Prof. dr. Frank Delvigne, University of Liège Gembloux, HES, Belgium

Helmholtz-Centre for Environmental Research – UFZ Leipzig,
REC, Germany
Puratos NV, SME, Belgium

Group photo ContiBio

ContiBio virtual Kick-off meeting (Photo: ContiBio Archive)


Project Abstract

The ContiBio project aims to control synthetic co-cultures in bioreactors by assembling a modular computational framework to address phenotypic and genetic instabilities arising at a single-cell level. The project will build a cell-machine interface based on our research efforts on microbial population interactions and dynamic single-cell data to transition from batch bioprocesses to continuous ones. This project will provide new technologies enabling the control and stability of continuous cultivation devices by addressing the phenotypic and genetic diversification found for industrial bioprocesses.

ContiBio is funded by the ERA CoBioTech partners: SPW-DGO6, and SMWK.

Project Start: May 2021   Duration: 36 months  
Project Budget:  Total Cost: 856.000 Euro, Funding: 798.000 Euro
Project Website:


Project brochure

HES – higher education sector – university
REC – research organisation
SME – small and medium-sized enterprise