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DNA Helix

Cofund on Biotechnologies

Innovation for Europe – life science meets market application


Microbial conversion of lignin to monomers for bio-based plastics using synthetic biology



Coordinator: prof. dr. Timothy Bugg, University of Warwick, HES, United Kingdom

University of Stuttgart,
HES, Germany
Spanish National Research Council (CSIC), REC, Spain
Institut National de la Recherche Agronomique (INRA), REC, France
nova-Institut GmbH, SME, Germany
Biome Technologies plc, SME, United Kingdom

Group photo MILIMO

Photo: Dr Stéphanie Baumberger


Project Abstract

The aim of the MILIMO project is to use metabolic engineering in Rhodococcus jostii RHA1 and Pseudomonas putida KT2440 to produce pyridine-dicarboxylic acid (PDCA) bioproducts from lignin feedstocks, in commercially viable yield. The project will use synthetic biology methods to enhance the rate of lignin oxidation in Rhodococcus jostii RHA1 and Pseudomonas putidaKT2440, and synthetic biology will also be used to redesign the metabolic pathways of Pseudomonas putidaKT2440 in order to optimise the production of PDCA monomers. If successful, the industrial partner in this Project, Biome Bioplastics Ltd (UK), will seek to develop new polyester bioplastics containing PDCA monomers.

MILIMO is funded by the ERA CoBioTech partners: UKRI-InnovateUK, BMBF, AEI and ANR.

Project Start: March 2020   Duration: 36 months  
Project Budget:  Total Cost: 1.658.000 Euro, Funding: 1.149.000 Euro
Project Website:


Project presentation status seminar 2021

Project brochure


HES – higher education sector – university
REC – research organisation
SME – small and medium-sized enterprise