Enzyme platform for the synthesis of chiral aminoalcohols
Coordinator: Prof. Dr. Wolf-Dieter Fessner, Technische Universität Darmstadt, HES, Germany
Consejo Superior de Investigaciones Científicas - CSIC - Institute of Advanced Chemistry of Catalonia -IAQC, PUB, Spain
Université Clermont Auvergne (UCA), HES, France
BASF SE, LE, Germany
University College London, HES, United Kingdom
Prozomix Ltd, SME, United Kingdom
The one-pot, multi-step biocatalytic synthesis of industrially useful chiral amino alcohols will be achieved through the combination of novel/engineered highly selective carboligases and aminotransferases. Amino alcohols are a class of diverse compounds that can be used as building blocks for the synthesis of pharmaceuticals and agrochemicals. So far, it is difficult and uneconomical to achieve their synthesis biocatalytically and economically. A multi-disciplinary approach, involving bioinformatics, organic synthesis, biochemistry, molecular biology, molecular modeling, and biocatalytic process development will be pursued. The aim is to discover and/or engineer a powerful and flexible enzyme toolbox for the biocatalytic syntheses of valuable chiral amino alcohols with broad industrial applications and to pilot key processes via the toolbox. The biocatalytic production of valuable, high in demand compounds will be accelerated and the paradigm will be set for their sustainable and greener industrial production, while at the same time minimizing environmental impact and creating value for the European economy and society .
TRALAMINOL is funded by the ERA CoBioTech partners: ANR, BMBF, AEI, UKRI-BBSRC, UKRI-InnovateUK and co-funded by the European Union.
HES – higher education sector – university
LE – large enterprise
SME – small and medium-sized enterprise
PUB – public body