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DNA Helix

Cofund on Biotechnologies

Innovation for Europe – life science meets market application


Synthetic microbial communities for the production of limonene derived products

Logo SyCoLim

Coordinator: prof dr. RodrigoLedesma-Amaro, Imperial College London (RLA) Surrey, HES, United Kingdom

Imperial College London (GBS),
HES, United Kingdom
Charité University Medicine Berlin, HES, Germany
Consejo Superior de Investigaciones Cientificas, REC, Spain
Acies Bio d.o.o., SME, Slovenia


Project Abstract

The aim of this project SyCoLim is to produce high-value chemicals (with applications as pharmaceuticals, medicines, fragrances, nutraceuticals or cosmetics) from waste raw materials (recycling glycerol, the by-product of biodiesel industries). In order to achieve this objective, synthetic microbial communities between yeast and bacteria will be created. These communities will be engineered to present advantages over monocultures, such as division of labour, higher adaptability and robustness or an expanded metabolic network. The bioprocess carried out by the best strains generated will be scaled up in industrial conditions in the facilities of our industrial partner. Therefore, the project will help the lab-to-market transition of the sustainable production of valuable compounds and will combine this with the exploration of novel synthetic biology and microbial communities’ methodologies that have the potential to be applicable to other bioprocesses, thus facilitating the global transition towards the bioeconomy.

SyCoLim is funded by the ERA CoBioTech partners: UKRI-InnovateUK, BMBF, AEI and MIZS.

Project Start: January 2020    Duration: 36 months  
Project Budget:  Total Cost: 1.354.000 Euro, Funding: 1.119.000 Euro
Project Website:


Project presentation status seminar 2021

Project brochure



HES – higher education sector – university
REC – research organisation
SME – small and medium-sized enterprise