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DNA Helix

Cofund on Biotechnologies

Innovation for Europe – life science meets market application


Replacing food competing feedstocks with Methanol, CO2 and Methylamine for a Sustainable Bioeconomy


Coordinator: prof. dr. Trygve Brautaset, Norwegian University of Science and Technology (NTNU), Department of Biotechnology and Food Science, HES, Norway

Marmara University, Department of Bioengineering,
HES, Turkey
Bielefeld University Biology and Center for Biotechnology (CeBiTec), HES, Germany
Acies bio, d.o.o., SME, Slovenia
Aarhus University, Aarhus, HES, Denmark

Group photo MCM4SB

Hybrid project meeting @ Trondheim (NO) and online (Photo: MCM4SB Archive)


Project Abstract

The MCM4SB project aims to replace sugar-based feedstocks for bioprocesses with one carbon (C1) compounds, namely methanol (CH3OH), carbon dioxide (CO2) and methylamine (CH3NH2) in order to establish a novel, sustainable production within a low-fossil-fuel bio-economy. Renewable methanol currently is produced e.g. by catalytic reduction of CO2 at the 700,000 tons per annum scale. Methylamine is present in fish wastes and is available from CO2 by direct reduction in the presence of ammonia or indirectly via green methanol. This project aims to combine utilization of methanol with CO2 and/or methylamine for production of the bulk chemical L-malate and the ERA CoBioTech MCM4SB - ID: 30 3 of 37 specialty chemical N-methyl-L-glutamate.

MCM4SB is funded by the ERA CoBioTech partners: RCN, MIZS, and TUBITAK.

Project Start: April 2021   Duration: 36 months  
Project Budget:  Total Cost: 1.221.000 Euro, Funding: 876.000 Euro
Project Website:


Project presentation status seminar 2021

Project brochure


HES – higher education sector – university
SME – small and medium-sized enterprise